Why does resveratrol cause joint pain
Resveratrol may even provide more benefits for people with diabetes than those who don't have. Healthy people seem to tolerate them well ( 47 ). I have some experience to share. Experimentally, COX2 inhibitors look to reduce the severity of joint inflammation in arthritis models ( ). Yet vitamin D is also known to help promote healthy joints, as well as bones! However, much of the research on resveratrol has been done in animals and test tubes using high amounts of the compound ( 5, 8 ). However, the authors of that study say more research is needed before specific recommendations can be made about the best dose of resveratrol to maximize blood pressure benefits.
A 2016 study fed mice pain a high-protein, high-polyunsaturated fat diet and also gave them resveratrol supplements. And there are some cautions, especially regarding how resveratrol could interact with other medications. The top food sources include red wine, grapes, some berries and peanuts ( 5, 6 ). So you don't hear about. This article explains what you need to know about resveratrol, including seven of its main potential health benefits. However, clear dosage guidance is still lacking. As an antioxidant, they may also decrease LDL cholesterol odixation.
I knew about these things, and felt that the overwhelmingly positive findings about resveratrol made it worth trying. Of the limited research in humans, most has focused on supplemental forms of the compound, in concentrations higher than those you could get through food ( 5 ). In one study, participants were given grape extract that had been boosted with extra resveratrol. However, it's not clear if they would have a similar effect in humans. It May Increase Insulin Sensitivity Resveratrol has been shown to have several benefits for diabetes, at least in animal studies. People doing studies to prove the commercial value of this compound aren't going to step up with suspected problems. This may partly be due to the antioxidant and anti-inflammatory activity of resveratrol. A friend of mine had his Achilles tendon rupture after taking Cipro eight years ago, and a little research revealed that this was a common side effect.
Cyclo-oxygenase 2 (COX2) is one key enzyme involved in inflammation. And no matter what male bodybuilders joint would say, the experts have shown that men do need some estrogen too (.gov/pubmed/17937464, m ). There's evidence that resveratrol activates certain genes that ward off the diseases of aging ( 17 ). Summary: Resveratrol has helped mice develop better insulin sensitivity and fight complications of diabetes.
One study injected resveratrol into the knee joints of rabbits with arthritis and found that these rabbits suffered less damage to their cartilage ( 34 ). But beyond being a healthful part of red wine and other foods, resveratrol has health-boosting potential in its own right. My recommendation is: Don't mess with resveratrol. Interestingly, vitamin D looks to be an aromatase inhibitor too ( ). So, speculatively, perhaps the COX2 suppressive actions of vitamin D override the aromatase-inhibiting actions of vitamin least in your case. Since high doses have been shown to stop blood from clotting in test tubes, it's possible it could increase bleeding or bruising when taken with anti-clotting drugs, such as heparin or warfarin, or some pain relievers ( 48, 49 ).
Near the end, I noticed strange sharp occasional pains in one Achilles tendon. Dehydration and yeasty foods (bread and beer!) can cause a rise in uric acid, which causes the pain. It is a favourite among bodybuilders because it may down play aromatase and may be well absorbed unlike some other natural sources (e.g. After making the Achilles connection, I immediately stopped resveratrol and started taking copper and other "regular" vitamins.
Additionally, the compound may set off a chain of events that protects brain cells from damage ( 21 ). The knee pain has essentially disappeared after a few weeks. That type of pressure is called systolic blood pressure, and appears as the upper number in blood pressure readings. A review of studies exploring this connection found that resveratrol increased lifespan in 60 of the organisms studied, but the effect was strongest in organisms that were less related to humans, such as worms and fish ( 20 ). Summary: Resveratrol supplements may help lower blood pressure by increasing the production of nitric oxide.